The Doppler velocity signal refers to a signal whose voltage is proportional to the Doppler frequency shift, obtained by a frequency-to-voltage conversion of the Doppler signal.

See also Autocorrelation, Temporal Mean Velocity, Doppler Effect, Doppler Ultrasound and Maximum Venous Outflow.

Different stages of the drug development and approval process in the USA, lead from preclinical trials (testing in animals), first application in humans through limited and broad clinical tests, to postmarketing studies.


By Dale E. Wierenga, Ph.D. and C. Robert Eaton
Office of Research and Development
Pharmaceutical Manufacturers Association

'In reviewing this report, it is important to keep in mind the realities of the drug discovery and development process. The U.S. system of new drug approvals is perhaps the most rigorous in the world. On average, it costs a company $359 million to get one new medicine from the laboratory to the pharmacist's shelf, according to a February 1993 report by the Congressional Office of Technology Assessment.'

See also Phase 1 2 3 4 Drug Trials, Food and Drug Administration, and European Medicines Agency.

Dual frequency phased array transducers allow performing third or fourth harmonic imaging. This array design contains two different types of elements arranged in an interleaved pattern (odd and even elements). The elements can work individually and at a distinct frequency enabling separate transmission and receiving modes.

Duplex ultrasonography (duplex scan) consists of two ultrasound modalities to study blood flow and the perivascular tissue. This includes B-mode / gray scale imaging used in combination with spectral Doppler / pulsed-wave Doppler.
The real-time visualization of the vessels and tissue by the B-mode component improves the PW Doppler positioning and the direction of blood flow can be inferred. The angle between the direction of the PW Doppler signal and the estimated direction of blood flow can be measured.
Duplex techniques are available on phased array, linear array, and mechanical scanners. A phased array probe is able to create nearly simultaneous images and flow information. A linear array transducer can also do this if the Doppler probe is attached separately to one end of the scanhead. A mechanical transducer freeze the image; the crystals must be static to produce a Doppler image. The first two transducers are therefore the best choice for Duplex.

See also Compound B-Mode, and Duplex Scanner.

Duplex systems often combine a pulsed Doppler with a spectral display and a real time imaging system. A duplex scanner has usually an imaging transducer or a separate transducer used to collect continuous wave or pulsed Doppler signals, either simultaneously with imaging or sequentially.