This coefficient is a quantification of the energy intensity loss of waves (electromagnetic or mechanical) due to attenuation. In ultrasound imaging it is the relative energy intensity loss per traveled centimeter. The ultrasound attenuation coefficient is measured in units of dB/cm. The attenuation coefficient in soft tissues is nearly proportional to the ultrasound frequency. The attenuation coefficient is doubled when the frequency is doubled.
This coefficient (dB/cm) divided by the frequency (MHz) is almost constant in a given tissue.

B-flow is an ultrasound imaging mode, which shows flowing blood as well as the vessel walls.

Also called B-mode echography, B-mode sonography, 2D-mode, and sonogram.
B-mode ultrasound (Brightness-mode) is the display of a 2D-map of B-mode data, currently the most common form of ultrasound imaging.
The development from A-mode to B-mode is that the ultrasound signal is used to produce various points whose brightness depends on the amplitude instead of the spiking vertical movements in the A-mode. Sweeping a narrow ultrasound beam through the area being examined while transmitting pulses and detecting echoes along closely spaced scan lines produces B-scan images. The vertical position of each bright dot is determined by the time delay from pulse transmission to return of the echo, and the horizontal position by the location of the receiving transducer element.
To generate a rapid series of individual 2D images that show motion, the ultrasound beam is swept repeatedly. The returning sound pulses in B-mode have different shades of darkness depending on their intensities. The varying shades of gray reflect variations in the texture of internal organs. This form of display (solid areas appear white and fluid areas appear black) is also called gray scale.

Different types of displayed B-mode images are:
The probe movement can be performed manual (compound and static B-scanner) or automatic (real-time scanner).
The image reconstruction can be parallel or sector type.

See also B-Scan, 4B-Mode, and Harmonic B-Mode Imaging.

B-scan ultrasonography, or B-scan, is a diagnostic test, for example used in ophthalmology to produce a two-dimensional, cross-sectional view of the eye and the orbit. The presentation of the reflected pulses are displayed in rectangular coordinates, in which the travel time of an ultrasound pulse is represented as a shift along one axis, and the probe movement is represented as a shift along the other axis.

See also Ultrasound Imaging Procedures, A-Scan, C-Scan and D-Scan.

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From POINT Biomedical Corp
BiSphere™ is a technology for drug delivery applications by ultrasound. BiSpheres™ consists of microparticles comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microbubbles contains a filling gas, liquid, or solid for use in drug delivery or as a contrast agent for ultrasonic contrast imaging. The contrast agent particles are capable of passing through the capillary systems of a subject. The drug-loaded biSpheres™ would be administered intravenously and freely circulate throughout the body, while the drug encapsulated within would remain biologically unavailable. The drug would only be released when the biSpheres become flooded when passing through an externally directed ultrasound field.
The use of biSpheres™ to transport agents to specific sites within the body is expected to substantially increase local efficacy while decreasing systemic side effects or adverse reactions. The biSpheres™ may also serve to protect labile agents from metabolism or degradation. The noninvasive release of a protected, encapsulated agent can be controlled by ultrasound imaging to a depth of 20-30 cm from the skin surface.
The flexibility in size control in the biSphere™ technology has enabled the construction of submicron ultrasound contrast agents suitable for lymphatic imaging, with a diameter in the submicron range. This agent, while much smaller in size than CardioSphere®, is based on the BiSphere configuration: a shell within a shell enclosing a gas. The inner layer, made from a biodegradable polymer, provides the physical structure and controls the acoustic response. The outer layer functions as the biological interface. Each of these layers has been independently tailored to fulfill the specific requirements for lymphatic imaging.