[This entry is marked for removal.]

From Acusphere Inc
AI-700 (trade name Imagify™) is an US contrast agent, usable for myocardial perfusion undergoing regulatory FDA approval. The synthetic polymers used in AI-700 (perflubutane polymer microspheres) do not break during the ultrasound imaging procedure. The used perfluorocarbon filling gas is less soluble in water and therefore has the propensity to stay inside the contrast agent particles. As a result, a higher concentration of gas is delivered to the myocardium over a longer period of time, thereby enabling AI-700 to target the broader application of myocardial perfusion assessment.
Imagify is a dry powder consisting of small, porous microparticles filled with perfluoropropane. These microparticles are made of a synthetic biodegradable polymer, called poly (D, L-lactide co-glycolide), or PLGA, that has been used in other drug delivery systems approved by the FDA.
The composition and structure of the phospholipid containing microparticles and the properties of the perfluorocarbon gas slow the rate at which the gas dissolves and prevent the microparticles from being quickly broken down. The powder is to suspend in sterile water and injected by a single intravenous injection prior to ultrasound imaging.

In 2009, Acusphere Inc received feedback from the Food and Drug Administration (FDA) to their New Drug Application (NDA) stating that another clinical trial would be required for U.S. approval, this one demonstrating that Imagify with ultrasound is superior to ultrasound without Imagify.
In June 2004, Acusphere entered into a Collaboration, License and Supply Agreement with Nycomed Danmark APS for the European development and marketing rights to Acusphere's lead product candidate AI-700.
Acusphere's focus will be on preparing the Marketing Authorization Application (MAA) for filing in Q4 2010, building upon the work that the previous partner, Nycomed, had done, in concert with the NDA.


In 2008 the FDA panel rejected the regulatory application for AI-700 (Imagify™) because of safety concerns.

Brachytherapy is a radiation therapy in which radioactive material (radioisotopes) sealed in needles, seeds or wires is placed directly into or near a tumor. Brachytherapy uses ultrasound imaging to visualize the needles for accurate placement of the small seeds or pellets (capsules) directly into e.g., the prostate. Ultrasound imaging allows accurate planning, placement and implantation of the radiation sources. Implantation of the seeds is a minimally invasive procedure.
Radioactive seeds are inserted through the perineum skin (the area between the scrotum and the anus) into the prostate gland. With correct planning, the surgeon can implant the radiation sources for maximum benefits to effective cancer treatment.

See also EchoSeed™, Prostate Ultrasound, Thermotherapy, High Intensity Focused Ultrasound, Urologic Ultrasound, Transurethral Sonography.

Environmental protection in ultrasound imaging involves adopting practices and technologies that minimize the environmental impact associated with the use of ultrasound equipment and disposables.

Here are some key considerations:

By focusing on energy efficiency, digitalization, waste management, equipment lifespan, and education, healthcare facilities can make significant strides towards reducing their carbon footprint and the environmental impact of ultrasound imaging practices.

See also Ultrasound System Performance, Equipment Preparation, Ultrasound Accessories and Supplies and Sonographer.

Diagnostic ultrasound imaging has no known risks or long-term side effects. Discomfort to the patient is very rare if the sonogram is accurately performed by using appropriate frequencies and intensity ranges. However, the application of the ALARA principle is always recommended.
There are reports of low birth weight of babies after applying more than the recommended ultrasound examinations during pregnancy. Women who think they might be pregnant should raise this issue with the doctor before undergoing an abdominal ultrasound, to avoid any harm to the fetus in the early stages of development.
Since ultrasound is energy, sensitive tissues like the reproductive organs could possibly sustain damage if vibrated to a high degree by too intense ultrasound waves. In diagnostic ultrasonic procedures, such damage would only result from improper use of the equipment.

Possible ultrasound bioeffects:
The thermal effect is controlled by the displayed thermal index and the mechanical index indicates the risk of cavitation.
An ultrasound gel is applied to obtain better contact between the transducer and the skin. This has the consistency of thick mineral oil and is not associated with skin irritation or allergy.
Specific conditions for which ultrasound may be selected as a treatment may be attached with higher risks.

See also Ultrasound Imaging Procedures, Fetal Ultrasound and Obstetric and Gynecologic Ultrasound.

Common ultrasound supplies that are often used in conjunction with ultrasound imaging:
Common ultrasound accessories that are often used in conjunction with ultrasound imaging:
Consult with ultrasound equipment vendors or professionals in the field to determine the specific accessories and supplies that best suit your imaging needs and specialty. See also Equipment Preparation, Environmental Protection, Portable Ultrasound Machine, Ultrasound Technology, Ultrasound System Performance and Sonographer.