[This entry is marked for removal.]

'POINT Biomedical was a privately held pharmaceutical company, founded in 1996 to pursue technologies related to imaging and drug delivery. POINT's core technology was based upon an ultrasonically responsive two-layer, biodegradable microsphere or BiSphere™. One of the most important features of this technology is the ability to noninvasively trigger the BiSpheres™ to release their contents at sites within the body using externally generated pulses of ultrasound. From this basic platform, POINT was developing a pipeline of products that leverage the unique properties of the BiSphere™ technology in the areas of imaging and therapeutics. POINT has initially focused development of this platform on the assessment of tissue specific blood flow. The lead product, CARDIOsphere®, is a pharmaceutical agent that will enable cardiologists to perform myocardial perfusion imaging studies in the office setting using ultrasound rather than more expensive and cumbersome nuclear medicine (or radioisotope) techniques.'
'According to BioSpace, Tom Feldman, ex-CEO of Point BioMedical, the company's lead investor, Vendanta Capital has chosen not to follow through with the second half of its $50 million private equity financing. Point BioMedical has withdrawn the new drug application for its molecular imaging agent CARDIOsphere and is liquidating its assets to avoid a formal bankruptcy proceeding in 2008.'

Pressure is the force per unit area applied on a surface in a direction perpendicular to that surface.
Pressure can also be described as a form of potential energy in a fluid. The maximum pressure of the fluid medium obtained during propagation of an ultrasonic pulse.
The negative peak pressure is the peak rarefaction pressure attained during the negative portion of a propagating ultrasound pulse in a medium such as tissue.
Sound pressure can be measured using a microphone in air and a hydrophone in water. The SI unit for sound pressure is the Pascal.
Blood pressure is the pressure exerted by the blood on the walls of the blood vessels.

See also Rarefactional Pressure, Low Intensity Pulsed Ultrasound, and Projector.

Range gating utilized the selection of a returning ultrasound wave according to its depth by receiver activation at the appropriate time delay. The ultrasonic signal is selected by the range gate.

Rayleigh scattering is the backscattering of ultrasound from blood. The echoes detected from blood are created through interference between scattered wavelets from numerous point scatterers. Rayleigh Scatterers are objects whose dimensions are much less than the ultrasound wavelength. Rayleigh scattering increases with frequency raised to the 4th power and provides much of the diagnostic information from ultrasound. Doubling the ultrasonic frequency makes the echoes from blood 16 times as strong. The intensity of the backscattered echoes is proportional to the total number of scatterers, which means that the echo amplitude is proportional to the square root of the total number of scatterers.
At normal blood flow, the number of point scatterers in blood is proportional to the number of red blood cells. When blood flow is turbulent, or accelerating fast (e.g. in a stenosis), the number of inhomogeneities in the red blood cell concentration will increase.

See also Scattered Echo.

The reflector is a stationary plate component of a flowprobe used in Doppler ultrasound. Each transducer alternately emits an ultrasound beam which is reflected from this reflector to the receiving transducer. The fixed distance of the reflective pathway is critical to the measurement of the ultrasonic transit time and the accurate measurement of volume flow.

See also Target Strength.