A flowmeter derives an accurate measure of the transit time ; transit time (or time of flight) is the difference in time for an ultrasonic pulse to travel with the direction of flow and against it. With bi-directional illumination it is the time taken for an ultrasound pulse to travel from one transducer to another. This time is used to measure blood flow rate. The difference between the upstream and downstream measured transit times calculates the volume flow.

See also Echo Ranging.

For the flowprobe a vessel is positioned between transducers which generate wide beams of ultrasound to fully illuminate the vessel. The ultrasound beams alternately intersect the flowing blood in upstream and downstream directions. The flowmeter derives an accurate measure of the changes in transit time influenced by the motion of the blood.

See also Bi-directional Flow.

A bolus is a rapid infusion of high dose contrast agent. Dynamic and accumulation phase imaging can be performed after bolus injection. Since the transit time of the bolus is only a short time, images with high frame rate show the wash in and wash out of the contrast material. The injection rate and the total injected volume modifies the bolus peak profile. Substantial changes in the concentrations during signal acquisition induce artifacts. Furthermore, the hemodynamic parameters (cardiac output, blood pressure) influence the bolus profile. However, the characteristics of ultrasound contrast agents are favorable with a continuous perfusion.

See also Negative Bolus.

Echo ranging is the ultrasound relationship between transit time and reflector depth expressed as:
t = 2d//c

The reflector is a stationary plate component of a flowprobe used in Doppler ultrasound. Each transducer alternately emits an ultrasound beam which is reflected from this reflector to the receiving transducer. The fixed distance of the reflective pathway is critical to the measurement of the ultrasonic transit time and the accurate measurement of volume flow.

See also Target Strength.