Medical Ultrasound Imaging
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Doppler Techniques
Doppler techniques are dependent on the transducers used. The transducer operating in continuous wave mode utilizes one half of the elements and is continuously sending sound energy while the other half is continuously receiving the reflected signals. If the transducer is being used in a pulsed wave mode, the whole transducer is used to send and then receive the returning signals.
Pulsed wave techniques allow the accurate measurement of blood flow at a specific area in the heart and the detection of both velocity and direction. Measurement is performed by timing the reception of the returning signals giving a view of flows at specific depths. The region where flow velocities are measured is called the sample volume. Errors in the accuracy of the information arise if the velocities exceed a certain speed. The highest velocity accurately measured is called the Nyquist limit.
Continuous Wave Doppler
Used for accurate measurement of high Velocity flow. A disadvantage is the poor range of resolution.
Pulsed Wave Doppler
Used for the measurement of velocities at a specific location with a good range of resolution. A disadvantage is the imprecise measuring of high velocities.

See also Doppler Velocity Signal and Doppler Effect.
History of Ultrasound
The earliest introduction of vascular ultrasound contrast agents (USCA) was by Gramiak and Shah in 1968, when they injected agitated saline into the ascending aorta and cardiac chambers during echocardiographic to opacify the left heart chamber. Strong echoes were produced within the heart, due to the acoustic mismatch between free air microbubbles in the saline and the surrounding blood.
In 1880 the Curie brothers discovered the piezoelectric effect in quartz. Converse piezoelectricity was mathematically deduced from fundamental thermodynamic principles by Lippmann in 1881.
In 1917, Paul Langevin (France) and his coworkers developed an underwater sonar system (called hydrophone) that uses the piezoelectric effect to detect submarines through echo location.
In 1935, the first RADAR system was produced by the British physicist Robert Watson-Wat. Also about 1935, developments began with the objective to use ultrasonic power therapeutically, utilizing its heating and disruptive effects on living tissues. In 1936, Siemens markets the first ultrasonic therapeutic machine, the Sonostat.
Shortly after the World War II, researchers began to explore medical diagnostic capabilities of ultrasound. Karl Theo Dussik (Austria) attempted to locate the cerebral ventricles by measuring the transmission of ultrasound beam through the skull. Other researchers try to use ultrasound to detect gallstones, breast masses, and tumors. These first investigations were performed with A-mode.
Shortly after the World War II, researchers in Europe, the United States and Japan began to explore medical diagnostic capabilities of ultrasound. Karl Theo Dussik (Austria) attempted to locate the cerebral ventricles by measuring the transmission of ultrasound beam through the skull. Other researchers, e.g. George Ludwig (United States) tried to use ultrasound to detect gallstones, breast masses, and tumors. This first experimentally investigations were performed with A-mode. Ultrasound pioneers contributed innovations and important discoveries, for example the velocity of sound transmission in animal soft tissues with a mean value of 1540 m/sec (still in use today), and determined values of the optimal scanning frequency of the ultrasound transducer.
In the early 50`s the first B-mode images were obtained. Images were static, without gray-scale information in simple black and white and compound technique. Carl Hellmuth Hertz and Inge Edler (Sweden) made in 1953 the first scan of heart activity. Ian Donald and Colleagues (Scotland) were specialized on obstetric and gynecologic ultrasound research. By continuous development it was possible to study pregnancy and diagnose possible complications.
After about 1960 two-dimensional compound procedures were developed. The applications in obstetric and gynecologic ultrasound boomed worldwide from the mid 60's with both, A-scan and B-scan equipment. In the late 60's B-mode ultrasonography replaced A-mode in wide parts.
In the 70's gray scale imaging became available and with progress of computer technique ultrasonic imaging gets better and faster.
After continuous work, in the 80's fast realtime B-mode gray-scale imaging was developed. Electronic focusing and duplex flow measurements became popular. A wider range of applications were possible.
In the 90's, high resolution scanners with digital beamforming, high transducer frequencies, multi-channel focus and broad-band transducer technology became state of the art. Optimized tissue contrast and improved diagnostic accuracy lead to an important role in breast imaging and cancer detection. Color Doppler and Duplex became available and sensitivity for low flow was continuously improved.
Actually, machines with advanced ultrasound system performance are equipped with realtime compound imaging, tissue harmonic imaging, contrast harmonic imaging, vascular assessment, matrix array transducers, pulse inversion imaging, 3D and 4D ultrasound with panoramic view.

Huygens Principle
Huygens principle states that an expanding sphere of waves behaves as if each point on the wave front were a new source of radiation of the same frequency and phase. The principle explains how a flat ultrasound transducer can transmit a narrow ultrasound beam, which in the near field is confined to the dimensions of the transducer surface.
Spherical wavelets are emitted from numerous point sources on the transducer surface. They interfere to form a narrow, slightly converging beam of ultrasound in the near field. The wavefronts in the beam are nearly parallel. A precondition for this interference is that the transducer surface is much larger than the ultrasound wavelength.

See also Interference Artifact.
Ultrasound Elastography
Ultrasound elastography is a specialized imaging technique that provides information about tissue elasticity or stiffness. It is used to assess the mechanical properties of tissues, helping to differentiate between normal and abnormal tissue conditions.
The basic principle behind ultrasound elastography involves the application of mechanical stress to the tissue and measuring its resulting deformation. This is typically achieved by using either external compression or shear waves generated by the ultrasound transducer.
There are two main types of ultrasound elastography:
Strain Elastography: In strain elastography, the tissue is mechanically compressed using the ultrasound transducer, causing deformation. The transducer then captures images before and after compression, and the software analyzes the displacement or strain between these images. Softer tissues tend to deform more than stiffer tissues, and this information is used to generate a color-coded map or elastogram, where softer areas appear in different colors compared to stiffer regions.
Shear Wave Elastography: Shear wave elastography involves the generation of shear waves within the tissue using focused ultrasound beams. These shear waves propagate through the tissue, and their velocity is measured using the ultrasound transducer. The speed of shear wave propagation is directly related to tissue stiffness: stiffer tissues transmit shear waves faster than softer tissues. By calculating the shear wave velocity, an elastogram is generated, providing a quantitative assessment of tissue stiffness.

Both strain elastography and shear wave elastography offer valuable insights into tissue characteristics and can assist in the diagnosis and characterization of various conditions. In clinical practice, ultrasound elastography is particularly useful for evaluating liver fibrosis, breast lesions, thyroid nodules, prostate abnormalities, and musculoskeletal conditions. By providing additional information about tissue stiffness, ultrasound elastography enhances the diagnostic capabilities of traditional ultrasound imaging. It allows for non-invasive assessment, improves the accuracy of tissue characterization, and aids in treatment planning and monitoring of various medical conditions.
See also Ultrasound Accessories and Supplies, Sonographer and Ultrasound Technology.
Doppler Effect
Christian Johann Doppler first described the effect of motion of sound sources and the frequency change of the sound to the observer.
Doppler ultrasound uses this effect to detect and measure blood flow, and the major reflector is the red blood cell. Doppler ultrasound depends on the fact that if the reflecting surface is moving in relation to the transducer (blood flowing in a vessel) the frequency of the received ultrasound wave will be different from that of the transmitted wave. If blood cells are moving towards the transducer, they increase the frequency of the returning signal. As cells move away from the transducer, the frequency of the returning signal decreases.

See also Quadrature Detection and Doppler Techniques.
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 [last update: 2023-11-06 01:42:00]