Release burst imaging is a method based on the combination of multiple high frequency, broadband-detection pulses with a separate release burst. Release burst imaging is optimally suited to the characteristic of ultrasound contrast agents.
This method allows to improve both contrast sensitivity and imaging resolution. Imaging and transient enhanced scattering can be optimized separately. The release burst mode can be combined with a Doppler method to remove residual clutter signals from moving tissue.

See also Repetition Rate.

Clutters are unwanted components of the received signal. In contrast enhanced ultrasound, clutter often describes the part of the received echo that is not from microbubble contrast agents.

See also Release Burst Imaging.

Standard scanners allow visualizing microbubbles on conventional gray scale imaging in large vascular spaces. In the periphery, more sensitive techniques such as Doppler or non-linear gray scale modes must be used because of the dilution of the microbubbles in the blood pool. Harmonic power Doppler (HPD) is one of the most sensitive techniques for detecting ultrasound contrast agents.
Commonly microbubbles are encapsulated or otherwise stabilized to prolong their lifetime after injection. These bubbles can be altered by exposure to ultrasound pulses. Depending on the contrast agent and the insonating pulse, the changes include deformation or breakage of the encapsulating or stabilizing material, generation of free gas bubbles, reshaping or resizing of gas volumes.
High acoustic pressure amplitudes and long pulses increase the changes. However, safety considerations limit the pressure amplitude and long pulses decrease spatial resolution. In addition, lowering the pulse frequency increases destruction of contrast bubbles. However, at low insonation power levels, contrast agent particles resist insonation without detectable changes. Newer agents are more reflective and will usually allow gray scale imaging to be used with the advantages of better spatial resolution, fewer artifacts and faster frame rates.

Feasible imaging methods with advantages in specific acoustic microbubble properties:
Resonating microbubbles emit harmonic signals at double their resonance frequency. If a scanner is modified to select only these harmonic signals, this non-linear mode produces a clear image or trace. The effect depends on the fact that it is easier to expand a bubble than to compress it so that it responds asymmetrically to a symmetrical ultrasound wave. A special array design allows to perform third or fourth harmonic imaging. This probe type is called a dual frequency phased array transducer.

See also Bubble Specific Imaging.

Pulsed ultrasounds are cycles of ultrasound separated in time with gaps of no signal. Pulsed sound waves are generated by short, strong pulses of sound from a phased array of piezoelectric crystals. The transducer, though emitting ultrasound in rapid pulses, acts as a receiver most of the time. In sonography, pulsed ultrasound is used to perform diagnostic or therapeutic procedures.

See also Pulse Average Intensity, Release Burst Imaging.