Interference is the interplay of two or more waveforms. When two or more waves with equal frequency and wavelength interfere, a new wave is created whose amplitude at any point in time and space is the sum of the amplitudes of the original waves at the same point in time and space. Constructive interference occurs when two waves of equal frequency are in phase. The amplitudes will always be in the same direction, and the waves will combine to produce a stronger one. Two equally strong waves with the same amplitude that are 180° out of phase will cancel each other out.

See also Interference Artifact.

Interference artifacts occur if decreasing of the echo amplitude is not exponential with penetration depth caused by inhomogeneous tissue layers and fluid or air-filled regions. If ultrasound waves have opposite phases, i.e. if the phase difference is 180°, their amplitudes will always be in opposite directions and their sum is a weaker wave. This is destructive interference and artifacts occur.

Linear scattering occur from specular reflectors or tissue, in which the echo is an accurate copy of the incident ultrasound pulse. If the phase or amplitude of the transmitted sound is altered, the phase or amplitude of the echo will be also altered.
Non-linear scatterers, such as microbubbles, do not follow these rules.

The propagation of high amplitude ultrasound waves is inadequate described by a linear wave equation. Non-linear propagation is to expect if the power levels are high enough to make non-linear effects significant. A non-linear propagation results in the distortion of the transmitted waveforms, resulting in the generation of harmonics of the initial frequency components transmitted by the transducer.
In the near field of ultrasound probes, the occurring diffraction and focusing effects make this process complex. The distortion of a wavefront propagating in a medium in which the compressional phase moves slightly faster than the rarefactional phase, results is the conversion of some wave energy into higher harmonics of the fundamental frequency. The effect increases strongly with increasing wave amplitude.

Speckle noise affects the quality of the ultrasound images and can mask pathology. This artifact can be reduced by using a phase insensitive technique, or by canceling the undesirable linear-phase representation. More system samplings (needs more channels and memory) or a fuzzy logic algorithm can filter out the speckle noise.