Phase in ultrasound describes where the sound wave is in its cycle of amplitude change. Different waves oscillate at different frequencies, so time is often not a suitable measure of phase.
The phase shift is a difference in the phase or the temporal offset of the peaks of a waveform along one scan line.

See also Coherence, and Histogram.

A phased array probe applies voltage pulses to all elements as a group but with small time differences (phasing). The time difference is changed each time so that the sound pulses will be sent out in different directions.

Different stages of testing drugs in humans for example ultrasound contrast agents, from first application in humans through limited and broad clinical tests, to postmarketing studies. Preclinical trials are the testing in animals.

See also Drug Development and Approval Process USA, Food and Drug Administration, and European Medicines Agency.

Dual frequency phased array transducers allow performing third or fourth harmonic imaging. This array design contains two different types of elements arranged in an interleaved pattern (odd and even elements). The elements can work individually and at a distinct frequency enabling separate transmission and receiving modes.

Different stages of the drug development and approval process in the USA, lead from preclinical trials (testing in animals), first application in humans through limited and broad clinical tests, to postmarketing studies.


By Dale E. Wierenga, Ph.D. and C. Robert Eaton
Office of Research and Development
Pharmaceutical Manufacturers Association

'In reviewing this report, it is important to keep in mind the realities of the drug discovery and development process. The U.S. system of new drug approvals is perhaps the most rigorous in the world. On average, it costs a company $359 million to get one new medicine from the laboratory to the pharmacist's shelf, according to a February 1993 report by the Congressional Office of Technology Assessment.'

See also Phase 1 2 3 4 Drug Trials, Food and Drug Administration, and European Medicines Agency.