Brachytherapy is a radiation therapy in which radioactive material (radioisotopes) sealed in needles, seeds or wires is placed directly into or near a tumor. Brachytherapy uses ultrasound imaging to visualize the needles for accurate placement of the small seeds or pellets (capsules) directly into e.g., the prostate. Ultrasound imaging allows accurate planning, placement and implantation of the radiation sources. Implantation of the seeds is a minimally invasive procedure.
Radioactive seeds are inserted through the perineum skin (the area between the scrotum and the anus) into the prostate gland. With correct planning, the surgeon can implant the radiation sources for maximum benefits to effective cancer treatment.

See also EchoSeed™, Prostate Ultrasound, Thermotherapy, High Intensity Focused Ultrasound, Urologic Ultrasound, Transurethral Sonography.

Contrast agents improve the sensitivity of vascular Doppler ultrasound, for example in cerebrovascular sonography or examinations of deep abdominal vessels. They also enlarge the role of transcranial Doppler. Microbubbles can be used with various modes e.g., color and power Doppler imaging, as well as pulsed-wave Doppler to increase the signal intensity. However, the ultrasound system must be suitable for contrast enhanced technology.
Microbubbles usually stay within the vascular space; nevertheless, the contrast enhancement is limited to 2−6 minutes caused by physiologic clearance and bubble destruction.
Depended on the application, contrast agents can be administered with a different injection rate e.g., bolus injection, slow injection, or continuous infusion. Stable, homogeneous, and prolonged enhancement can be obtained with perfusion, lasting until the infusion is stopped.

See also Cerebrovascular Ultrasonography, Multiple Frame Trigger.

Densitometry in ultrasound refers to measurement of the gray level intensity of an image region. Ultrasound image gray levels usually have non-linear relationships to the echo amplitude that makes densitometry not suitable for evaluation of contrast images.

(DI) The directivity index is the value in dB of ten times the common logarithm of the directivity factor. The directivity factor is the ratio of the sound intensity produced by a test transducer on a specific axis to that of a point source that is emitting the same acoustic power. Since the specific axis is usually one of maximum radiation, the directivity index is usually greater than zero.

See also dB/dt.

The far field (also called Fraunhofer zone) is the distal part of an ultrasound beam characterized by a diverging shape and continuous loss of ultrasound intensity with distance from the transducer. The angle of divergence increases with lower transducer frequency and with smaller transducer diameter.

See also Sonographic Features.