2D ultrasound imaging is a widely used technique in medical imaging that provides two-dimensional visual representations of internal structures. A handheld device known as a probe or transducer contains piezoelectric crystals that emit and receive ultrasound waves which penetrate tissues and bounce back as echoes. The echoes are detected and converted into electrical signals. These signals are processed and displayed on a monitor, creating a real-time 2D grayscale image, with different shades of gray representing various tissue densities. The brighter areas on the image correspond to structures that reflect more ultrasound waves, while darker areas represent structures that reflect fewer waves or are attenuated by intervening tissues. The 2D-mode (or B-mode) provides cross-sectional views of the scanned area, showing a single plane or slice of the scanned area at a time.

Key Features and Uses of 2D Ultrasound:

Comparison with 3D and 4D Ultrasound:
See also Ultrasound Technology, Sonographer, Ultrasound Elastography, Obstetric and Gynecologic Ultrasound.

Berlex Laboratories has been integrated into Bayer HealthCare, and operates as an integrated specialty pharmaceuticals business under a new name, Bayer HealthCare Pharmaceuticals.
The company is developing and making specialized medicines for treating multiple sclerosis, dermatological disorders, female health concerns, cancer and is creating new diagnostic imaging techniques. Berlex Laboratories, Inc. was a pioneer in the imaging market. It introduced a broad range of imaging agents. Its contribution began in 1988 with the introduction of the world's first magnetic resonance imaging agent, Magnevist® (gadopentetate dimeglumine) injection. Berlex Laboratories, Inc. was an US affiliate of Bayer Schering Pharma AG Germany.

Common ultrasound supplies that are often used in conjunction with ultrasound imaging:
Common ultrasound accessories that are often used in conjunction with ultrasound imaging:
Consult with ultrasound equipment vendors or professionals in the field to determine the specific accessories and supplies that best suit your imaging needs and specialty. See also Equipment Preparation, Environmental Protection, Portable Ultrasound Machine, Ultrasound Technology, Ultrasound System Performance and Sonographer.

From Bracco Diagnostics, Inc.
SonoVue® was first launched in October 2001 and is now available in all European countries.
SonoVue is a second generation USCA, designed and optimized with regard to the resistance to pressure. SonoVue is an example of an important family of microbubbles whose membrane consists of phospholipids. SonoVue microbubbles are filled with sulfur hexafluoride (SF6), a gas which has a low solubility and diffuses slowly in blood for the gaseous phase of the microbubbles.
In particular, the SonoVue microbubbles, thanks to the high flexibility of their shell, are strongly echogenic in a wide range of frequencies and acoustic pressure and therefore can be used with both destructive and conservative contrast bubble specific imaging methods.

See also Coherent Contrast Imaging.

Standard scanners allow visualizing microbubbles on conventional gray scale imaging in large vascular spaces. In the periphery, more sensitive techniques such as Doppler or non-linear gray scale modes must be used because of the dilution of the microbubbles in the blood pool. Harmonic power Doppler (HPD) is one of the most sensitive techniques for detecting ultrasound contrast agents.
Commonly microbubbles are encapsulated or otherwise stabilized to prolong their lifetime after injection. These bubbles can be altered by exposure to ultrasound pulses. Depending on the contrast agent and the insonating pulse, the changes include deformation or breakage of the encapsulating or stabilizing material, generation of free gas bubbles, reshaping or resizing of gas volumes.
High acoustic pressure amplitudes and long pulses increase the changes. However, safety considerations limit the pressure amplitude and long pulses decrease spatial resolution. In addition, lowering the pulse frequency increases destruction of contrast bubbles. However, at low insonation power levels, contrast agent particles resist insonation without detectable changes. Newer agents are more reflective and will usually allow gray scale imaging to be used with the advantages of better spatial resolution, fewer artifacts and faster frame rates.

Feasible imaging methods with advantages in specific acoustic microbubble properties:
Resonating microbubbles emit harmonic signals at double their resonance frequency. If a scanner is modified to select only these harmonic signals, this non-linear mode produces a clear image or trace. The effect depends on the fact that it is easier to expand a bubble than to compress it so that it responds asymmetrically to a symmetrical ultrasound wave. A special array design allows to perform third or fourth harmonic imaging. This probe type is called a dual frequency phased array transducer.

See also Bubble Specific Imaging.