(Hb) Hemoglobin is the major endogenous oxygen-binding molecule, responsible for binding oxygen in the lung and transporting it to the tissues by means of the circulation. Hemoglobin is contained in very high concentration in the red blood cells.
Hemoglobin is a Fe chelate tightly binding one Fe ion in its II oxidation state where it carries the charge 2+. If an oxygen molecule is bound to Hb, Hb is called oxyhemoglobin, if no oxygen molecule is bound it is called deoxyhemoglobin. When hemoglobin is oxidized (i.e. in a hematoma), Fe2+ is transformed into Fe3+. The resulting hemoglobin is then called metoxyhemoglobin (Hb Fe3+).

(CHI) Contrast harmonic imaging is an ultrasound technique to improve the measurement of blood perfusion or capillary blood flow. Based on the nonlinear properties of contrast agents, CHI transmits at the fundamental frequency but receives at the second harmonic. Contrast enhanced echo signals contain significant energy components at higher harmonics (bubbles acts as harmonic oscillators), while tissue echoes do not. Caused by that contrast signal can be separated from tissue echoes by the characteristic signal.
In combination with the pulse inversion technique, CHI promises very high contrast agent sensitivity with high spatial resolution.

See also Ultrasound Contrast Agent Safety and Hemoglobin.

Echocardiography is the ultrasound examination of the heart. Depending on the used ultrasound system, echocardiograms can be two-dimensional slices or 3D real-time images of the heart. Based on the ultrasound principles the direction and speed of blood flow can be utilized e.g., to diagnose a leaking or stenosed valve or to identify intracardiac shunts.

Different types of echocardiography:
The transthoracic echocardiogram (images are taken through the chest wall) is a non-invasive, highly accurate and quick assessment of the overall health of the heart.
A more invasive method is to insert a specialized scope containing an echocardiography transducer (TEE probe) into the esophagus, and record images from there. The advantages are clearer images, since the transducer is closer to the heart.
Contrast echocardiogram (CE) is already a valuable tool to delineate endocardial borders, direct invasive procedures, detect intracardiac shunts, assess myocardial perfusion and viability, and quantify coronary flow reserve and blood volumes (see also hemoglobin). The mechanism of microbubble CE is based on the physical principles of rarefaction and compression, leading to volume pulsations of microbubbles, and it is this change that results in CE signal.
Stress echocardiograms are echocardiography exams used for detection of coronary artery disease.

See also Diastole, Bicycle Stress Echocardiography, Resistive Index, and M-Mode Echocardiography.

Hemodynamics describes the physical principles and forces involved in blood circulation.

See also Hemoglobin.