Bubble destruction describes the microbubble shell rupture by ultrasound pulses. The bubble destruction increases with increasing peak negative pressure and decreasing frequency. The mechanical index is an indicator for the effectiveness of microbubble destruction. Contrast enhanced ultrasound relies on bubble rupture to detect bubbles in small vessels.

See also Negative Bolus.

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From POINT Biomedical Corp
CARDIOsphere® is an ultrasound contrast agent for assessment of myocardial perfusion in patients with coronary artery disease composed of highly echogenic bispheres.
PB127 is a new developed microbubble with a bilayer polymer/albumin shell filled with nitrogen gas that has ideal characteristics for power harmonic Doppler. They can be destroyed by high power ultrasound, and spectral decorrelation between ultrasound pulses is maximized by rapid dissolution of the released nitrogen gas.
POINT Biomedical Corp. announced (March 01, 2004) that it has completed two Phase 3 trials of CARDIOsphere®. The Phase 3 trials were designed to evaluate the performance of CARDIOsphere® imaging relative to radionuclide imaging for detecting obstructive coronary artery disease and identifying the anatomic location of perfusion defects.

Cardiac ultrasound, also known as echocardiography or echocardiogram, is used to provide several different levels and types of heart testing. Cardiac ultrasound utilizes the same ultrasound principles as used for obstetric and gynecologic evaluations of pregnant women, gallbladder ultrasound and other abdominal structures.
The ultrasound is directed out of a hand held probe which can be moved to image the heart from different positions. Additionally, so that heart events can be timed, ECG leads are placed on the chest. The reflected wave is converted into an actual image of the heart and displayed in a real-time mode or M-mode ultrasound format. M-mode recordings permit measurement of cardiac dimensions and detailed analysis of complex motion patterns depending on transducer angulations. Also the time relationships with other physiological variables such as ECG, heart sounds, and pulse tracings, can be recorded simultaneously. A stress echocardiogram provides information about the cardiac performance.
Two-dimensional tomographic images of selected cardiac sections give more information than M-mode about the shape of the heart and also show the spatial relationships of its structures during the cardiac cycle (diastole to systole).

See also M-Mode Echocardiography, and Myocardial Contrast Echocardiography.

(CAI) Color amplitude imaging shows the amplitude of the Doppler signal from moving blood flow. CAI is an ultrasound technique with increased dynamic range and flow sensitivity. The sensitivity of Doppler ultrasound increases markedly in conjunction with the use of vascular contrast agents.

See also Amplitude Map, Amplitude Indicator.

(CDI) Color Doppler imaging depicts the mean frequency shifts of the Doppler signal. Color [colour, Brit.] Doppler imaging is a method for visualizing direction and velocity of movement, such as of blood flow within the cardiac chambers or blood vessels. The flow direction and velocity information gathered by Doppler ultrasonography is color coded onto a gray scale cross-sectional image. The sensitivity of Doppler ultrasound is increased in conjunction with the use of vascular contrast agents.
Direction and blood flow velocity are coded as colors and shades:
Red - flow coming nearer to the probe.
Blue - flow coming away of the probe.

See also Bi-directional Illumination, Color Map.